Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

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Title Date published
#526: Building Data Science with Foundation LLM Models 2025-11-01
#525: NiceGUI Goes 3.0 2025-10-27
#524: 38 things Python developers should learn in 2025 2025-10-20
#523: Pyrefly: Fast, IDE-friendly typing for Python 2025-10-13
#522: Data Sci Tips and Tricks from CodeCut.ai 2025-10-06
#521: Red Teaming LLMs and GenAI with PyRIT 2025-09-29
#520: pyx - the other side of the uv coin (announcing pyx) 2025-09-23
#519: Data Science Cloud Lessons at Scale 2025-09-18
#518: Celebrating Django's 20th Birthday With Its Creators 2025-08-29
#517: Agentic Al Programming with Python 2025-08-22
#516: Accelerating Python Data Science at NVIDIA 2025-08-19
#515: Durable Python Execution with Temporal 2025-08-11
#514: Python Language Summit 2025 2025-07-18
#513: Stories from Python History 2025-07-14
#512: Building a JIT Compiler for CPython 2025-07-02
#511: From Notebooks to Production Data Science Systems 2025-06-25
#510: 10 Polars Tools and Techniques To Level Up Your Data Science 2025-06-18
#509: GPU Programming in Pure Python 2025-06-11
#508: Program Your Own Computer with Python 2025-06-06
#507: Agentic AI Workflows with LangGraph 2025-06-02
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